Scientific Basis

BrEx uses a validated microsimulation model to estimate the survival benefits of different levels of physical activity for breast cancer survivors. The model accounts for individual characteristics — including cancer stage, hormone receptor status, treatment history, and age at diagnosis — to generate personalized estimates of all-cause survival across four exercise levels.

The underlying science draws on peer-reviewed research linking physical activity to improved outcomes in breast cancer survivors, including reduced risk of cancer recurrence and all-cause mortality. The model was developed and validated using data from large prospective studies and has been published in peer-reviewed journals.

Full details on the studies, publications, and references that form the scientific basis of this tool will be available in a future version of this site.